Modified GRF 1-29 (also known as CJC-1295 without DAC) is a Growth Hormone Releasing Hormone (GHRH). And is categorized as a growth hormone secretagogue, a compound which stimulates increased secretion of growth hormone from the pituitary gland. Although similar to Sermorelin, Mod-GRF has four amino acid substitutions made to its chemical structure. Hence the alternate name “tetrasubstituted” GRF 1-29. These changes effectively increase the stability of Mod GRF during storage. And transportation, and administration while enhancing its affinity for the GHRH receptor.
HISTORY OF MOD-GRF 1-29
The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure. This fragment became known as GRF (1-29). However. And due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity. And reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide. And structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala).
In 2005, the first specific mention of tetrasubstitued GRF (1-29) appeared in a study that used it as one of the GRF (1-29) analogue peptide structures studied. The term was used to describe the replacement of the 2nd, 8th, 15th. And 27th amino acids in the structure of GRF (1-29).
In 2008, a researcher known as DatBtrue created the term modified GRF (1-29) in place of tetrasubstitued. And GRF (1-29) in his public articles. Continued use of the term on public and private forums has popularized. And standardized the nomenclature.(SOURCE: wikipedia)
DOSAGE OF MOD-GRF 1-29
Amount per administration: 100mcg.
Administration frequency: 1 to 3 times daily.
Dosages of 100mcg per administration is generally administered 1-3 times daily. 100mcg can be administered once daily before bed for anti-aging purposes. This protocol can provide a significant increase in growth hormone production over time while still mirroring natural patterns of GH release. For strength gain or performance enhancement, 100mcg can be administered 3 times a day in combination with a GHRP (as mentioned above). The higher dosage of Mod GRF in conjunction with the use of a GHRP can provide a substantial increase in growth hormone output. This will facilitate muscle growth, fat loss, and recovery from training and injury.
SIDE EFFECTS OF MOD-GRF 1-29
Feelings of tiredness or lethargy are possible as well. And as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities.
These reactions tend to dissipate after repeated injections.
Excessive dosages of Mod GRF 1-29 may also lead to tingling or numbness in the hands and feet. Water retention can be another sign that the dosage is too high and should be reduced.